Harnessing the power of the chicken immune system
Immune Biosolutions integrates powerful technologies to generate premium quality antibodies. Immunogen design algorithms, antigen synthesis, immunogenic adjuvants, recombinant antibody and humanization strategies, all optimized to exploit the untapped avian antibody repertoire.
Chicken IgY antibodies
Untapped, distinct and superior
Immune Biosolutions combines the considerable avian-mammalian phylogenetic distance with self-versus non-self-immune activation. Mammalian proteins are more immunogenic in chickens, and this results in better epitope coverage as well as increased antibody diversity and affinity. Mammalian IgG and avian IgY are both divalent and monomeric, and produced by analogous immune systems. Since, the variable regions of IgG and IgY are structurally similar, an IgY-derived single chain variable fragment (ScFv) can seamlessly undergo ultrahumanization, giving access to a novel therapeutic antibody repertoire.
Integrated antibody design and engineering
Nebula is a technology platform for generating therapeutic and diagnostic antibodies with outstanding attributes. With the untapped avian antibody repertoire at its core, Nebula integrates three-dimensional peptide design algorithms and synthesis with high-throughput phage-display selection strategies as well as recombinant antibody engineering.
Consistent tailored fit
Phage display libraries generated form the lymphoid cells of immunized chickens are probed against the target antigen. The best binding clones are sequenced and can be expressed a variety of formats according to the desired therapeutic applications.
3D conformation-specific antibodies
Spatial antibodies are raised against peptides that adopt a three-dimensional conformation mimicking the target in its native environment. This alleviates traditional antibody generation hurdles, and enables to tackle highly-structured or transmembrane domain-containing targets, such as GPCR and ion channels for which no other antibodies generation strategy previously succeeded.