Why target GPCRs with antibodies?
The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in the body, GPCRs relay signals from outside the cell, across the membrane, to intracellular signaling pathways.
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