{"id":4747,"date":"2026-06-23T09:45:36","date_gmt":"2026-06-23T13:45:36","guid":{"rendered":"https:\/\/immunebiosolutions.com\/?page_id=4747"},"modified":"2026-06-23T09:46:41","modified_gmt":"2026-06-23T13:46:41","slug":"affinity-maturation","status":"publish","type":"page","link":"https:\/\/immunebiosolutions.com\/en\/affinity-maturation\/","title":{"rendered":"Affinity Maturation"},"content":{"rendered":"\n

Immune Biosolutions, in collaboration with 9Bio Therapeutics<\/a>, offers several pipeline for optimization of your existing antibodies.<\/p>\n\n\n\n

How Affinity Maturation Evolved in vivo<\/em><\/h2>\n\n\n\n

Affinity maturation is a natural process that evolved to generate of high affinity antibodies as a response to invading pathogens. This allows efficient immune response and increased survival. In chickens specifically, paratope diversity stems exclusively from somatic hypermutations. <\/p>\n\n\n

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Immunization to exploit natural affinity maturation<\/h2>\n\n\n\n

This process is used to generate high-affinity antibodies through the immunization process.<\/p>\n\n\n

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Offered Affinity Maturation Pipelines<\/h3>\n\n\n\n

Affinity may be optimized for antibodies by targeting permissive positions within the complementarity-determining regions (CDRs), enabling sequence diversification while preserving antigen recognition. We offer affinity maturation services across three levels of computational support, ranging from substitution matrices to advanced structure-guided engineering and molecular dynamics-driven optimization, allowing each campaign to be tailored to the desired balance of speed, depth, and predictive power.<\/p>\n\n\n