{"id":3927,"date":"2025-11-10T16:07:00","date_gmt":"2025-11-10T21:07:00","guid":{"rendered":"https:\/\/immunebiosolutions.com\/?page_id=3927"},"modified":"2026-05-13T16:31:21","modified_gmt":"2026-05-13T20:31:21","slug":"bispecific-and-multispecific-antibodies","status":"publish","type":"page","link":"https:\/\/immunebiosolutions.com\/en\/bispecific-and-multispecific-antibodies\/","title":{"rendered":"Bispecific and Multispecific Antibodies"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bispecific antibody pipelines<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Knob-into-hole IgG (with common light chain)<\/h3>\n\n\n\n<p>Knob-into-hole is the most prevalent bispecific antibody format and has been a part of our pipeline.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"380\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-1024x380.png\" alt=\"\" class=\"wp-image-3406\" style=\"width:1145px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-1024x380.png 1024w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-600x223.png 600w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-300x111.png 300w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-150x56.png 150w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-768x285.png 768w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1-900x334.png 900w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/08\/2025_Figures_BiSpecific-1.png 1145w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Antibody Fusion Protein<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"641\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-1024x641.jpeg\" alt=\"\" class=\"wp-image-4060\" style=\"width:559px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-1024x641.jpeg 1024w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-scaled-600x376.jpeg 600w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-300x188.jpeg 300w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-150x94.jpeg 150w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-768x481.jpeg 768w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-1536x962.jpeg 1536w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-2048x1283.jpeg 2048w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-1200x752.jpeg 1200w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-900x564.jpeg 900w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/IgG-protein-1500x940.jpeg 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">IgG-scFv<\/h3>\n\n\n\n<p>We have designed and generated a number of bispecific IgG-scFv. Our optimized constructs and pipeline are available for clients.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"477\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-1024x477.jpeg\" alt=\"\" class=\"wp-image-4270\" style=\"width:953px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-1024x477.jpeg 1024w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-300x140.jpeg 300w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-150x70.jpeg 150w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-768x358.jpeg 768w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-1536x715.jpeg 1536w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-1200x559.jpeg 1200w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-900x419.jpeg 900w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-1500x699.jpeg 1500w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1-600x279.jpeg 600w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-11-1.jpeg 1883w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">ScFv-scFv<\/h2>\n\n\n\n<p>Other formats of bispecific antibodies are also possible and could be optimized for clients.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"978\" height=\"1024\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-978x1024.jpeg\" alt=\"\" class=\"wp-image-3987\" style=\"width:572px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-978x1024.jpeg 978w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-600x628.jpeg 600w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-286x300.jpeg 286w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-143x150.jpeg 143w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-768x804.jpeg 768w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-859x900.jpeg 859w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv-900x943.jpeg 900w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-scfv.jpeg 1078w\" sizes=\"auto, (max-width: 978px) 100vw, 978px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Trispecific antibodies<\/h2>\n\n\n\n<p>Immune Biosolutions has a solid design and production pipeline available to clients for multispecific antibodies.<\/p>\n\n\n<style>.kb-row-layout-id3927_994f42-ea > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id3927_994f42-ea > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id3927_994f42-ea > .kt-row-column-wrap{column-gap:80px;row-gap:20px;max-width:var( --global-content-width, 1280px );padding-left:var(--global-content-edge-padding);padding-right:var(--global-content-edge-padding);padding-top:9px;padding-bottom:7px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id3927_994f42-ea > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id3927_994f42-ea > .kt-row-column-wrap{padding-top:70px;padding-bottom:70px;grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id3927_994f42-ea > .kt-row-column-wrap{padding-top:40px;padding-right:20px;padding-bottom:40px;padding-left:20px;grid-template-columns:minmax(0, 1fr);}}<\/style><section class=\"kb-row-layout-wrap kb-row-layout-id3927_994f42-ea alignfull wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top kb-theme-content-width\">\n<style>.kadence-column3927_e599b1-3f > .kt-inside-inner-col,.kadence-column3927_e599b1-3f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column3927_e599b1-3f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column3927_e599b1-3f > .kt-inside-inner-col{flex-direction:column;}.kadence-column3927_e599b1-3f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column3927_e599b1-3f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column3927_e599b1-3f{position:relative;}@media all and (max-width: 1024px){.kadence-column3927_e599b1-3f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column3927_e599b1-3f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column3927_e599b1-3f\"><div class=\"kt-inside-inner-col\">\n<h3 class=\"wp-block-heading\">IgG and IgG-scFv<\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"660\" height=\"789\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-12.jpeg\" alt=\"\" class=\"wp-image-4273\" style=\"width:241px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-12.jpeg 660w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-12-251x300.jpeg 251w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-12-125x150.jpeg 125w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/Antibody-Formats-12-600x717.jpeg 600w\" sizes=\"auto, (max-width: 660px) 100vw, 660px\" \/><\/figure>\n<\/div><\/div><\/div>\n\n\n<style>.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col,.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col{flex-direction:column;}.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column3927_0ccfe5-87{position:relative;}@media all and (max-width: 1024px){.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column3927_0ccfe5-87 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column3927_0ccfe5-87\"><div class=\"kt-inside-inner-col\">\n<h3 class=\"wp-block-heading\">Multiple scFv and monobodies<\/h3>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"578\" height=\"501\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-3-3.jpeg\" alt=\"\" class=\"wp-image-4034\" style=\"width:470px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-3-3.jpeg 578w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-3-3-300x260.jpeg 300w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/scfv-3-3-150x130.jpeg 150w\" sizes=\"auto, (max-width: 578px) 100vw, 578px\" \/><\/figure>\n<\/div><\/div>\n\n<\/div><\/section>\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"555\" src=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-1024x555.jpeg\" alt=\"\" class=\"wp-image-4010\" style=\"width:534px;height:auto\" title=\"\" srcset=\"https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-1024x555.jpeg 1024w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-600x325.jpeg 600w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-300x163.jpeg 300w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-150x81.jpeg 150w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-768x416.jpeg 768w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-1536x832.jpeg 1536w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-1200x650.jpeg 1200w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-900x488.jpeg 900w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole-1500x813.jpeg 1500w, https:\/\/immunebiosolutions.com\/wp-content\/uploads\/2025\/11\/tri-knob-into-hole.jpeg 2036w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bispecific antibody pipelines Knob-into-hole IgG (with common light chain) Knob-into-hole is the most prevalent bispecific antibody format and has been a part of our pipeline. Antibody Fusion Protein IgG-scFv We have designed and generated a number of bispecific IgG-scFv. Our optimized constructs and pipeline are available for clients. ScFv-scFv Other formats of bispecific antibodies are&#8230;<\/p>\n","protected":false},"author":35,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-3927","page","type-page","status-publish","hentry"],"acf":[],"taxonomy_info":[],"featured_image_src_large":false,"author_info":{"display_name":"Laurence Tessier","author_link":"https:\/\/immunebiosolutions.com\/en\/author\/ltessieribiosolutions-com\/"},"comment_info":0,"_links":{"self":[{"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/pages\/3927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/users\/35"}],"replies":[{"embeddable":true,"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/comments?post=3927"}],"version-history":[{"count":3,"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/pages\/3927\/revisions"}],"predecessor-version":[{"id":4467,"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/pages\/3927\/revisions\/4467"}],"wp:attachment":[{"href":"https:\/\/immunebiosolutions.com\/en\/wp-json\/wp\/v2\/media?parent=3927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}